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In mammals, paracetamol is detoxified in the liver where, at low doses, sulfation and glucoronidation result in the formation of the inactive, non-toxic sulfate and glucuronid conjugates (Scheme 1)

Unwanted proteins are degraded by the 26S proteasome, which consists of a 20S core and a 19S regulatory subunit

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Table 1 shows the detailed inclusion, exclusion, and removal criteria

Reparon-Schuijt, C

1,23,24,25 In this article, we review the complex physiological roles and metabolism of uric acid and the interconnections of mechanisms between hyperuricemia and potential diseases